Wilms Tumor Ppt New Better -

A must move beyond the classic slides of histology and staging. Today’s audience expects:

Laparoscopic nephrectomy for Stage I tumors (<500g, no IVC thrombus) is now acceptable in selected centers (new data 2024 shows equivalent outcomes).

-catenin gene frequently co-occur with WT1 mutations, activating the Wnt signaling pathway.

Historical risk stratification was based on stage and histology (favorable vs. anaplastic). The "new" Wilms tumor management is increasingly guided by molecular biomarkers. wilms tumor ppt new

[Clinical Suspicion / Abdominal Mass] │ ▼ [Abdominal Ultrasound (Doppler)] ──► Assess mass & vascular patency (IVC) │ ▼ [Abdominal & Pelvic CT or MRI] ──► Evaluate local invasion & contralateral kidney │ ▼ [Chest CT] ──► Screen for pulmonary metastases Imaging Modalities

BMJ Best Practice (2025). Wilms' tumour.

Use a Venn diagram showing overlapping features of triphasic histology. A must move beyond the classic slides of

| Locus | Mutation Frequency | |-------|-------------------| | 11p15 epigenetic abnormalities (H19 epimutation or pUPD) | 69% | | WTX | 32% | | CTNNB1 | 15% | | WT1 | 12% | | TP53 | 5% |

Hematogenous metastases present beyond the abdomen. Most common sites are lungs, liver, bone, or brain.

Indicated for Stage III favorable histology and Stages II-IV with unfavorable histology. Historical risk stratification was based on stage and

Begin your presentation by establishing the clinical footprint of the disease to provide your audience with clear epidemiological context.

About 5–10% of Wilms tumors are classified as anaplastic histology (unfavorable histology). Tumors without anaplastic nuclear changes are classified as .